端粒酶是一种能延长端粒的逆转录酶，近年研究表明，端粒酶活性与细胞永生化和恶变密切相关。在恶性脑肿瘤中端粒酶呈明显活化状态，很可能是一种全新的恶性脑肿瘤标志物；端粒酶活性的检测对不同类型脑肿瘤的诊断及预后判断具有较高的临床价值，以限制端粒扩增为抗癌新靶点的方法为临床脑肿瘤的治疗提供了新的思路。
- 作 者：
- 胡火军
- 作者单位：
- 湖北宜昌市中心人民医院神经外科,443003
- 刊 名：
- 国外医学(神经病学神经外科学分册)
- 英文刊名：
- FOREIGN MEDICAL SCIENCES SECTION ON NEUROLOGY & NEUROSURGERY
- 年，卷(期)：
- 200229(1)
- 分类号：
- R74
- 关键词：
- 端粒端粒酶脑肿瘤肿瘤标志物
- 机标分类号：
- R73 R74
- 机标关键词：
- 端粒酶活性恶性脑肿瘤肿瘤标志物细胞永生化预后判断逆转录酶临床价值活化状态新靶点治疗诊断思路扩增抗癌检测方法变密
- 基金项目：
- DOI：
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