血液检测与PET-CT筛查结合可用于早期发现癌症 作者： 发布时间：/4/30 13:01:27 美国约翰霍普金斯大学Nickolas Papadopoulos、Bert Vogelstein、Kenneth W. Kinzler等研究人员合作发现，血液检测与PET-CT筛查结合可用于早期发现癌症。相关论文于4月28日在线发表于《科学》。
在一项针对10,006名未知患有癌症女性的前瞻性干预研究中，研究人员评估了多肿瘤血液测试与PET-CT成像相结合用于检测癌症的可行性和安全性。诊断性PET-CT独立证实了阳性血液检查。通过血液检测发现了26种癌症。其中15例接受了PET-CT成像，其中9例（60％）通过手术切除。 通过护理标准筛查发现了24种其他癌症，以及两种方法均未发现的46种。1.0％的受试者根据假阳性血液检查进行了PET-CT成像，而0.22％的受试者经历了无效的侵入性诊断。 这些数据表明，将多肿瘤血液检测与PET-CT结合可以安全地纳入常规临床护理，并有可能指导肿瘤治疗。 附：英文原文 Title: Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention
Author: Anne Marie Lennon, Adam H. Buchanan, Isaac Kinde, Andrew Warren, Ashley Honushefsky, Ariella T. Cohain, David H. Ledbetter, Fred Sanfilippo, Kathleen Sheridan, Dillenia Rosica, Christian S. Adonizio, Hee Jung Hwang, Kamel Lahouel, Joshua D. Cohen, Christopher Douville, Aalpen A. Patel, Leonardo N. Hagmann, David D. Rolston, Nirav Malani, Shibin Zhou, Chetan Bettegowda, David L. Diehl, Bobbi Urban, Christopher D. Still, Lisa Kann, Julie I. Woods, Zachary M. Salvati, Joseph Vadakara, Rosemary Leeming, Prianka Bhattacharya, Carroll Walter, Alex Parker, Christoph Lengauer, Alison Klein, Cristian Tomasetti, Elliot K. Fishman, Ralph H. Hruban, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos
Issue Volume: /04/28
Abstract: Abstract Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multi-cancer blood testing coupled with PET-CT imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. 1.0% of participants underwent PET-CT imaging based on false positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multi-cancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.
DOI: 10.1126/science.abb9601
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期刊信息 Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037官方网址：投稿链接：
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