英国癌研所前两日的报道:
/about-us/cancer-news/news-report/-02-27-liquid-biopsies-could-help-spot-genetic-faults-in-lung-cancer
肿瘤治疗前需要采样活检，根据病人的肿瘤某基因的突变情况而制定针对性的个性化治疗方案。但是肿瘤组织采样活检有创伤，或有的病人无法采或采不到。最近有越来越多的关于液体活检（Liquid biopsies）的研究提示血液检查也能提供基因突变信息而又不需要组织活检，发表在JAMA Oncology的这一篇新文章就提到:用肺癌病人的血液能有效地检测出一个叫做EGFR基因的突变状况。
肿瘤细胞的DNA会从血液中分离脱落而成“循环中的游离DNA”，而它可被用于识别导致不同类型的癌症的EGFR基因的突变状况。
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Experts believe the findings could aid future research by overcoming the difficulty of accessing some tumour samples.
The researchers analysed blood samples from patients with advanced non-small-cell lung cancer and looked for ‘circulating free DNA’ – bits of DNA shed from tumour cells that can be isolated from the blood.
They found that the tumour DNA present in blood samples could be used to identify different types of tumour-causing genetic faults in a gene called EGFR.
Blood samples could offer an alternative to tumour biopsies in lung cancer patients, according to European researchers.
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论文链接:EGFR Mutations in Non–Small-Cell Lung Cancer
也可以看一看这个视频解释:
/lung//12/22/top_lung_cancer_highlight__liquid_biopsies/
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